Sildenafil is a medication commonly used to treat erectile dysfunction (ED) in men. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. Sildenafil works by increasing blood flow to the penis during sexual stimulation, helping men achieve and maintain an erection.

Sildenafil inhibits the enzyme phosphodiesterase type 5, leading to an increase in the levels of cyclic guanosine monophosphate (cGMP). This, in turn, relaxes the smooth muscles in the blood vessels of the penis, allowing increased blood flow and promoting an erection.

It is primarily prescribed for the treatment of erectile dysfunction but can also be used in the management of pulmonary arterial hypertension.

Sildenafil is commonly known by its brand name Viagra, but it is also available under various generic names.

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